Monday, July 13, 2020

The Coronavirus Disease

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Hardi Talwani

Article Title

The Coronavirus Disease

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Global Views 360

Publication Date

July 13, 2020

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Computer generated representation of COVID-19 virions (SARS-CoV-2) under electron microscope

Computer generated representation of COVID-19 virions (SARS-CoV-2) under electron microscope | Source Felipe Esquivel Reed via Wikimedia

Severe acute respiratory syndrome-Coronavirus 2 (SARS-CoV-2) is a novel virus from the family of coronaviruses which causes COVID-19 i.e. Coronavirus Disease-2019. It is the successor of the SARS-CoV-1 which caused the SARS outbreak in the year 2003-2004. This is a positive-sense single-stranded RNA virus which has rapid mutation properties.

The etymology of the name suggests that 'Corona' comes from the Latin word corōna meaning crown, garland, or a wreath. When seen under an Electron Microscope, the virion which has a diameter of 50-200 nanometres looks like the solar corona hence named Coronavirus.

When the virus enters the body; it attaches itself to the binding site or the ACE 2 receptors of healthy lung cells through its spike protein. Then it enters the cell via this attachment and causes apoptosis or cell death. The virus also affects organs other than lungs such as the brain, heart and kidneys. The multiple impact points make it problematic for the researchers to create a vaccine in addition to its rapid mutation properties.

The disease might have a zoonotic origin i.e. the transmission occurs from animals to humans. On comparing the genomic sequences the Human Coronavirus strain is found to be 96% identical to Bat Coronavirus samples and 92% similar to the Pangolins samples. Human transmission of the disease takes place via air droplets when the infected person is coughing, sneezing or talking.

The first cases of this respiratory illness were reported to the World Health Organization (WHO) from Wuhan City, Hubei Province, China, on 31 December 2019. It is the first severe outbreak since the 2009 H1N1 Influenza Pandemic. Initially, it was supposed that the site of origination is Huanan Seafood Wholesale Market but, in May 2020 the negative samples tested, by  Chinese Center for Disease Control and Prevention, from the livestock market suggested that it was the site of the super spreading of the virus.

SARS-CoV-2 is known to have an average reproduction number of 2.2-2.6 which means that, on an average, one infected person can spread the infection to 2-3 people. Although if measures like social distancing are put into use, to reduce the exposure of the infected population, it leads to a significant reduction in transmission rates. The infection fatality rate (IFR) of COVID-19 in various studies till 16th June 2020 was projected to range 0.60% to 1% of infected people . However few studies suggested the IFR as high as 3.6%.

The testing of an individual takes place through a method known as real-time Reverse transcription Polymerization Chain reaction (rRT-PCR). The process of obtaining strains and testing the patients usually involves nasal swabs or sputum swabs; the results come in within a span of a few hours to a couple of days.

Currently, there are no known vaccines available for the virus or any specific antiviral treatments, but there are numerous vaccines in works all over the world to tackle COVID-19. Experts believe that the minimum time required to test a vaccine is 12 to 18 months.

Trials are also going on for the repurposed drugs or the drugs which are useful for treating other diseases and might be capable against COVID-19: Some of these drugs are Hydroxychloroquine, chloroquine, Remdesivir, Dexamethasone, Lopinavir-ritonavir, and Convalescent plasma.

The only current solutions for tackling the pandemic are social distancing, hand wash, hygiene and face masks.

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February 4, 2021 5:00 PM

Stonewall Riots: A Pillar In The Movement For American LGBTQIA+ Rights

The Stonewall Riots are globally remembered as the cornerstone of Pride Month, and rightfully so. Fifty-one years ago, a routine police raid on Stonewall Inn, a gay bar in New York turned into an upheaval against homophobic society, laws, and policing.

In the early hours of June 28, 1969, a police raid— often conducted on secret or private bars that exclusively served LGBTQIA+ patrons— turned its head on the New York Police Department.

The Stonewall riot in 1969 | Source: David via Flickr

Some accounts say that the pivotal moment came when few of the lesbians who were brutally shoved into a police wagon showed resistance. In response, the crowd lit up in anger and resistance. Instead of running away to save themselves, the patrons fought back, even leading to the police barricading themselves within the bar itself as they waited for backup.

The Stonewall riot in 1969 | Source: David via Flickr

News of the clash spread and more people gathered, throwing anything they could find: nickels, garbage cans, broken bottles, and yes, bricks too, though ‘the first brick’ may have been more myth than real. Eventually, it took the fire department and a riot squad to quell the riots on the first night.

Defiant, Stonewall reopened the next evening, and the confrontation between police and community members continued for the rest of the week, drawing hundreds and upto thousands of community members. A total of twenty one protestors were arrested over the week, with the majority being arrested on the first night itself.

It’s hard to pinpoint what exactly led to the Stonewall riots, or the status that it earned in present-day Pride and LGTBQ+ liberation movements. The movement for LGTBQ+ rights existed before Stonewall (if relatively subdued relative to what came after), and so did the concept of ‘Pride,’ in the form of ‘Personal Rights in Defense and Education’ (PRIDE) that went on to become the Advocate magazine.

Stonewall wasn’t even the first time the community clashed with the police. It has been postulated that the act of naming, “the first to be called the first,” and the decision of organizers to commemorate its anniversary in the form of ‘Christopher Street Liberation Day’ contributed largely to Stonewall becoming a permanent and popular fixture in LGBTQIA+ history and collective memory.  

Regardless of the contributing factors, the cultural impact of Stonewall on American and Western LGBTQIA+ communities was immediate and intense. It became the epicentre of a louder, more radical movement. The community had tried it the ‘respectable’ way through organisations such as Mattachine, but it didn’t get them anywhere.

The number of LGTBQ+ focused organisations and magazines soared after Stonewall, going from around two dozen to four hundred. These included radical organisations such as the Gay Liberation Front and Radicalesbians.

The year after Stonewall, Sylvia Rivera and Marsha P. Johnson, who were present at the riots and are considered transgender icons, created the Street Transvestite Action Revolutionaries (STAR), which focused on struggles of drag queens and trans and gender-non-conforming youth who often lived on the streets.

Stonewall Inn as it existed no longer stands, but the new Stonewall Inn in the same street and the park across it have been recently declared as a historic national monument.

The old Stonewall was not a luxurious bar in terms of drinks or furnishings. It was not a place frequented by upper or middle class, white, cisgender gay men. Being a dance bar whose patrons included working class or homeless LGBTQIA+ people and drag queens, it was often looked down upon. All of that changed in one week, and the spirit that shone in Stonewall that night continues to resonate and be celebrated in the hearts of all LGBTQIA+ people.

In light of the ongoing Black Lives Matter protests and the rioting that happened alongside, many LGBTQIA+ people on social media have responded to criticism by reminding people of Stonewall, and how the “first Pride” was a riot led by Black and Latin transgender women, gender non-conforming youth, and other LGBTQIA+ people of colour, the very people whose history and resistance has often been white-washed, diminished, or erased altogether.

As said by Martin Luther King Jr., “A riot is the language of the unheard.”

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