Monday, July 13, 2020

The Coronavirus Disease

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Hardi Talwani

Article Title

The Coronavirus Disease

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Global Views 360

Publication Date

July 13, 2020

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Computer generated representation of COVID-19 virions (SARS-CoV-2) under electron microscope

Computer generated representation of COVID-19 virions (SARS-CoV-2) under electron microscope | Source Felipe Esquivel Reed via Wikimedia

Severe acute respiratory syndrome-Coronavirus 2 (SARS-CoV-2) is a novel virus from the family of coronaviruses which causes COVID-19 i.e. Coronavirus Disease-2019. It is the successor of the SARS-CoV-1 which caused the SARS outbreak in the year 2003-2004. This is a positive-sense single-stranded RNA virus which has rapid mutation properties.

The etymology of the name suggests that 'Corona' comes from the Latin word corōna meaning crown, garland, or a wreath. When seen under an Electron Microscope, the virion which has a diameter of 50-200 nanometres looks like the solar corona hence named Coronavirus.

When the virus enters the body; it attaches itself to the binding site or the ACE 2 receptors of healthy lung cells through its spike protein. Then it enters the cell via this attachment and causes apoptosis or cell death. The virus also affects organs other than lungs such as the brain, heart and kidneys. The multiple impact points make it problematic for the researchers to create a vaccine in addition to its rapid mutation properties.

The disease might have a zoonotic origin i.e. the transmission occurs from animals to humans. On comparing the genomic sequences the Human Coronavirus strain is found to be 96% identical to Bat Coronavirus samples and 92% similar to the Pangolins samples. Human transmission of the disease takes place via air droplets when the infected person is coughing, sneezing or talking.

The first cases of this respiratory illness were reported to the World Health Organization (WHO) from Wuhan City, Hubei Province, China, on 31 December 2019. It is the first severe outbreak since the 2009 H1N1 Influenza Pandemic. Initially, it was supposed that the site of origination is Huanan Seafood Wholesale Market but, in May 2020 the negative samples tested, by  Chinese Center for Disease Control and Prevention, from the livestock market suggested that it was the site of the super spreading of the virus.

SARS-CoV-2 is known to have an average reproduction number of 2.2-2.6 which means that, on an average, one infected person can spread the infection to 2-3 people. Although if measures like social distancing are put into use, to reduce the exposure of the infected population, it leads to a significant reduction in transmission rates. The infection fatality rate (IFR) of COVID-19 in various studies till 16th June 2020 was projected to range 0.60% to 1% of infected people . However few studies suggested the IFR as high as 3.6%.

The testing of an individual takes place through a method known as real-time Reverse transcription Polymerization Chain reaction (rRT-PCR). The process of obtaining strains and testing the patients usually involves nasal swabs or sputum swabs; the results come in within a span of a few hours to a couple of days.

Currently, there are no known vaccines available for the virus or any specific antiviral treatments, but there are numerous vaccines in works all over the world to tackle COVID-19. Experts believe that the minimum time required to test a vaccine is 12 to 18 months.

Trials are also going on for the repurposed drugs or the drugs which are useful for treating other diseases and might be capable against COVID-19: Some of these drugs are Hydroxychloroquine, chloroquine, Remdesivir, Dexamethasone, Lopinavir-ritonavir, and Convalescent plasma.

The only current solutions for tackling the pandemic are social distancing, hand wash, hygiene and face masks.

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February 4, 2021 4:47 PM

Alija Izetbegović: Journey from prison to Bosnian Presidency

In a world that still holds up the burden of racisms and prejudice, the struggle of vanquishing differences between various religious sects and political groups that emerged vibrantly back in the late 20th century sets an exemplary path for leaders today to follow.

The legendary Bosnian leader, Alija Izetbegović, who dedicated his entire life in the process of protecting human rights of Bosnian Muslims who were subjected to brutal crimes and violence by the neighboring countries, with his visionary and revolutionary thoughts played an important role during the dramatic changes that took place post the World War II.  

Born in 1925, Alija was always driven by his strong moral compass. For him, his ethics and his moral principles served him as a winning weapon in all battles. According to him, ethics added meaning and purpose to life.

He studied from the ‘University of Sarajevo’ with a degree in arts, laws, and science. His life journey began when he first appeared in the frontline as a civil right activist of an organization established by Sheikh Muhammad Kharji and Sheikh Cassim Dobreje.

It was in 1946 that he was first arrested when he was a twenty-one year old youngster. He was condemned for being a part of a group/organization that expounded religious freedom and human rights. He was sentenced to jail for 3 years. Unfortunately, this wasn’t an end to his hardship. In 1949, young Izetbegović was once again imprisoned, as per the orders received from a special military court. This time he was given a five-year sentence. His crime - active support behind the Young Muslim Organization. Izetbegović spent his youth behind the bars thinking and strengthening his spirit of establishing a multicultural Bosnia once again.  

Later in August of 1983, Izetbegović along with eleven other scholars was sentenced to 14 years in prison. It was during this time that Izetbegović wrote his book, “Notes from Prison: 1983-88”. In his book, he encompasses his experience at the prison cell and how resistance grew in him during all these years.

Izetbegović soon faced national and international Media under his virtue of engagement with the social and political affairs of the country. In 1990, he founded the Party of Democratic Action (SDA) and won the elections with a majority in 1992. The man who spent years in jail yet, filled with optimism and encouragement, had made it through all the agonies and challenges life put him through. With his party gaining central power, Izetbegović was elected as the first President of the country. Later, he also announced Bosnia-Herzegovina an independent republic.

Although Izetbegović was now the president of a young republic country, an end to criticism and racial crimes was not yet achieved. During the Croat-Bosniak war in 1993, the Croats destroyed the Mostar bridge (also known as Stari Bridge). Underlining their catastrophic act falsely as strategically driven, the Croats through this destruction attacked the symbolic importance of the Bridge, which was to connect diverse communities across it.

Despite the sustained attacks and strenuous efforts of the neighboring countries to curb rising unity and ethnicity in Bosnia, the Bosnian Leader always taught his fellow countrymen and soldiers to be superior morally first. He believed that it is this superiority that will fetch them their ultimate goal. For him, instituting peace was a fundamental duty, a greater win, or “greater jihad” over any other military victory. Rising international pressure ultimately brought peace in 1995.

Finally, he stepped down from the presidential throne in 2000. After he grimly fell ill, the greatest revolutionary thinker died in 2003. His eternal story of life struggle is inspiring, making him worthy of the title “wise king”.

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